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The following menu user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control NCBI Skip to main content Skip to navigation Resources How To About NCBI Accesskeys Sign in to NCBI PubMed US National Library of Medicine National Institutes of Health Search termSearch database The following autocomplete user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSearch AdvancedHelp Result Filters The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to: Am Rev Respir Dis. 1989 Jan;139(1):126-33. Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease. Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE. Source Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822. Abstract Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation. PMID: 2492170 [PubMed - indexed for MEDLINE] The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control Publication Types, MeSH Terms, Substances The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control LinkOut - more resources Supplemental Content
Save items The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites View more options Related citations in PubMed Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD). [Eur Respir J. 1991] Effect of naloxone on maximal exercise performance and control of ventilation in COPD. [Chest. 1989] Lung function and exercise gas exchange in chronic heart failure. [Circulation. 1997] Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease. [Chest. 1993] Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. [Am J Respir Crit Care Med. 1996] See reviews... See all... Cited by 9 PubMed Central articles Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study. [Pulm Med. 2012] Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response. [Am J Respir Crit Care Med. 2011] Killing the symptom without killing the patient. [Can Fam Physician. 2010] See all... Related information Related Citations Compound Compound (MeSH Keyword) Substance Substance (MeSH Keyword) Cited in PMC Recent activity Clear Turn Off Effects of oral morphine on breathlessness and exercise tolerance in patients wi... PubMed See more... You are here: NCBI > Literature > PubMedWrite to the Help Desk Simple NCBI Directory GETTING STARTED NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials RESOURCES Chemicals & Bioassays Data & Software DNA & RNA Domains & Structures Genes & Expression Genetics & Medicine Genomes & Maps Homology Literature Proteins Sequence Analysis Taxonomy Training & Tutorials Variation POPULAR PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure FEATURED Genetic Testing Registry PubMed Health GenBank Reference Sequences Map Viewer Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI INFORMATION About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NLM NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Browsers | Accessibility | Contact National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA The following menu user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control NCBI Skip to main content Skip to navigation Resources How To About NCBI Accesskeys Sign in to NCBI PubMed US National Library of Medicine National Institutes of Health Search termSearch database The following autocomplete user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSearch AdvancedHelp Result Filters The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to: Am Rev Respir Dis. 1989 Jan;139(1):126-33. Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease. Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE. Source Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822. Abstract Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation. PMID: 2492170 [PubMed - indexed for MEDLINE] The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control Publication Types, MeSH Terms, Substances The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control LinkOut - more resources Supplemental Content
Save items The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites View more options Related citations in PubMed Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD). [Eur Respir J. 1991] Effect of naloxone on maximal exercise performance and control of ventilation in COPD. [Chest. 1989] Lung function and exercise gas exchange in chronic heart failure. [Circulation. 1997] Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease. [Chest. 1993] Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. [Am J Respir Crit Care Med. 1996] See reviews... See all... Cited by 9 PubMed Central articles Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study. [Pulm Med. 2012] Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response. [Am J Respir Crit Care Med. 2011] Killing the symptom without killing the patient. [Can Fam Physician. 2010] See all... Related information Related Citations Compound Compound (MeSH Keyword) Substance Substance (MeSH Keyword) Cited in PMC Recent activity Clear Turn Off Effects of oral morphine on breathlessness and exercise tolerance in patients wi... PubMed See more... You are here: NCBI > Literature > PubMedWrite to the Help Desk Simple NCBI Directory GETTING STARTED NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials RESOURCES Chemicals & Bioassays Data & Software DNA & RNA Domains & Structures Genes & Expression Genetics & Medicine Genomes & Maps Homology Literature Proteins Sequence Analysis Taxonomy Training & Tutorials Variation POPULAR PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure FEATURED Genetic Testing Registry PubMed Health GenBank Reference Sequences Map Viewer Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI INFORMATION About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NLM NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Browsers | Accessibility | Contact National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA
