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Since it was unearthed that the risks of hormone treatment outweighed the benefits, researchers have now been searching for a safe, natural way to reduce the outward symptoms of menopause.
Participants are being employed for a clinical trial of a treatment called MF101 manufactured by Bionovo, Inc. In its original clinical trial, women were provided by MF101 in the research with early proof rest from such signs as night sweats and hot flashes, without the dangers associated with hormone therapy.
The treatment being tested clinically targets only 1 of the 2 known estrogen receptors-the estrogen receptor beta. Lab data indicates that MF101 does not cause the proliferation of breast or uterine cancer cells the way in which hormone therapy can, making the medicine a better alternative to currently available hormone therapies.
In 2002, the Women's Health Initiative (WHI) Estrogen Plus Progestin Trial, with over 16,000 women members, was stopped early when it was found that the standard measure of combination hormone therapy increased the risk of breast cancer, swing, center problems, blood clots and dementia.
"Given the void that exists for a and effective treatment for menopausal symptoms, our purpose is always to discover and develop novel drugs such as MF101 that could diminish many of the symptoms that have traditionally been handled with hormones," said Dr. Mary Tagliaferri. Tagliaferri is co-author of "The New Menopause Book: The Authorities Help You Make Educated Choices on HRT, Natural Hormone Therapy, Natural Therapies, Old-fashioned Chinese Medicine And More" (Avery, 2006) and Chief Medical Officer of Bionovo, that will be developing the drug.
The clinical studies will require place underneath the directorship of distinguished analyst Dr. Deborah Grady at four leading academic medical centers.
Bionovo expects this Phase 2 trial to be done by the next quarter of 2007.
"If this new medicine proves to be effective, we are providing medical care providers with a treatment they could comfortably recommend to women encountering menopause," said Dr. Tagliaferri. open site in new window
