PruettLachance900
Fosamax is really a bisphosphonate drug used for osteoporosis and various other bone disorders. It's sold alone as well as in conjunction with vitamin D underneath the name Fosavance.
Side-effects
GI tract: most notable are benign side effects such as for example mild vomiting, dyspepsia, abdominal pains, wind, diarrhoea, or obstipation. A serious side-effect is definitely an ulceration of the esophagus due to alendronate, which might require hospitalization and extensive therapy. Duodenal and gastric ulceration.
General: infrequent instances of skin rash, rarely manifesting as Stevens-Johnson syndrome and toxic epidermal necrolysis, vision issues (uveitis, scleritis) and generalized muscle, joint, and bone pain (rarely severe) have been seen. In laboratory tests reduced calcium and phosphate values might be obtained but reflect action of the drug and are safe.
Osteonecrosis of the jaw, a side-effect of bisphosphonates.
Dose
Prophylaxis of osteoporosis in women: 5-10mg daily or 35-70mg weekly.
Treatment of osteoporosis in women and men : 10mg daily or 70mg weekly.
Osteoporosis under corticosteroids: 5mg daily or 35mg weekly in males and premenopausal females or those receiving concomitant HRT. In postmenopausal women not getting HRT the recommended dose is 10mg daily or 70mg weekly.
Paget's Disease: 40mg daily for six months.
The drug is to be taken only upon rising for the afternoon with plenty of water. Stay, walk or sit thirty minutes afterward to prevent esophageal damage. At least half an hour must certanly be waited before meals or other beverages than water are drawn in.
Connections
Diet, milk and drugs containing large levels of calcium, magnesium or aluminium (antacids ): the resorption of alendronate is decreased. At the least around 30 minutes must pass after consumption of alendronate before taking the product or drug.
Extremely active vitamin D analogues or fluorides: no data can be acquired. Concomitant treatment should really be avoided.
The excess beneficial effect of HRT (hormone replacement therapy) with estrogens/progestins or raloxifene in postmenopausal females remains to be elucidated, but no communications have been seen. The combination is consequently possible.
Intravenous ranitidine increases the oral bioavailability of alendronate. No clinical consequences are known.
The combination of NSAIDS and alendroate advances the threat of gastric ulcers. Both these drugs have the potential to irritate the upper gastro-intestinal mucosa.
Does Merck have a patent with this drug?
Yes, but the patent is set to expire in 2008 and Merck has lost a number of appeals to block a common model of the drug from being certified by the US FDA.
Now you can understand why there is a growing curiosity about Fosamax. When people begin looking for more information about Fosamax, you'll be in a position to see them with details.
Disclaimer
As medical advice the data presented here shouldn't be interpreted. Please consult your physician before taking Fosamax or some other medicine.
Permission is granted to reprint this informative article so long as no changes are made, and the complete resource field is roofed. save on
